In Southeast Asia and around the world, religion has played an undeniably important role in the history of human civilisation and continues to shape politics and social trends to this day. This is reflected in contemporary artistic expressions from across the region where evocations of religious references in art are contingent on broader cultural, social, political and historical forces. Motivated by intra-regional comparative studies of Southeast Asian art practices, my thesis investigates the relation between religion and art in Southeast Asia in the works of two contemporary Southeast Asian artists. In particular, I will compare the artistic strategies of Thai artist Kamin Lertchaiprasert and Filipino artist Norberto Roldan in engaging with Buddhist and Christian expressions respectively. Despite the differing cultural backgrounds and personal motivations of the two artists, this thesis proposes that both artists are interested in offering alternative understandings on the roles of religion in their respective Thai and Philippine societies, and that they employ a range of similar but also differing artistic strategies in their treatment of religious images and objects. In addition, I also propose that the insights gleaned from this comparative pairing can be useful entry points for further investigations into the multi-faceted roles and expressions of religion across contemporary Southeast Asian art.